Student’s name
Walden University
Course
Instruction
Month, Day, Year
Matrix Worksheet
Evidence-based practice (EBP) uses clinical inquiry to acquire evidence-based answers to improve practice. In this matrix worksheet, I will compare the various research articles that I selected from a literature search following a clinical inquiry. My clinical issue of interest was gastrointestinal upset after the use of antibiotics and other acute disorders. Antibiotics especially the broad-spectrum ones kill several types of bacteria in the gut and the system. This can lead to eradication or reduction in the normal flora of the gastrointestinal tract.
The reduction of this natural source of defense in the gut can lead to the proliferation and virulence of pathogenic bacteria. Probiotics are exogenous regimens either containing commensals or their substrates that maintain the normal flora in the body (Wang et al., 2020). This clinical inquiry aims at assessing the benefit of prophylactic administration of probiotic foods to prevent gastrointestinal effects of antibiotics used on the gut such as gastrointestinal upset.
My PICOT question stated: “Among patients with gastrointestinal retiled to microbial infections (P), does the use of probiotic foods (I) confer health benefits in improving their health (O) after 3 months (T)?” Several sources were searched and the following four articles were sued to provide evidence-based answers to the clinical questions.
| Full citation of the selected article | Article #1 | Article #2 | Article #3 | Article #4 |
| Skrzydło-Radomańska, B., Prozorow-Król, B., Cichoż-Lach, H., Majsiak, E., Bierła, J. B., Kanarek, E., Sowińska, A., & Cukrowska, B. (2021). The effectiveness and safety of multi-strain probiotic preparation in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled study. Nutrients, 13(3), 756. https://doi.org/10. 3390/nu13030756 |
Hibberd, A. A., Yde, C. C., Ziegler, M. L., Honoré, A. H., Saarinen, M. T., Lahtinen, S., Stahl, B., Jensen, H. M., & Stenman, L. K. (2019). Probiotic or synbiotic alters the gut microbiota and metabolism in a randomized controlled trial of weight management in overweight adults. Beneficial Microbes, 10(2), 121–135. https://doi.org/10. 3920/BM2018.0028 |
Rui, X., & Ma, S.-X. (2020). A retrospective study of probiotics for the treatment of children with antibiotic-associated diarrhea. Medicine, 99(23), e20631. https://doi.org/10.1097/ MD.0000000000020631 |
Arnold, L. E., Luna, R. A., Williams, K., Chan, J., Parker, R. A., Wu, Q., Hollway, J. A., Jeffs, A., Lu, F., Coury, D. L., Hayes, C., & Savidge, T. (2019). Probiotics for gastrointestinal symptoms and quality of life in autism: A placebo-controlled pilot trial. Journal of Child and Adolescent Psychopharmacology, 29(9), 659–669. https://doi.org/10. 1089/cap.2018.0156 |
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| Why you chose this article and/or how it relates to the clinical issue of interest (include a brief explanation of the ethics of research related to your clinical issue of interest) | This article addresses the use of probiotics and their efficacies and effectiveness. It is addressed by PICOT intervention and outcomes at the same time. | This article meets my timeline criterion for article selection and addresses my intervention and outcomes. This article was more concerned with the mechanism that I would use to explain the clinical benefits of probiotic use. | This article addresses my population/problem, intervention, and outcomes. Therefore, I selected it because of its features and date of publications – less than 5 years old
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